Review Neurosurg Clin N Am
Brain Tumor Vaccines
Justin Lee 1, Benjamin R Uy 1, Linda M Liau 2Affiliations expand
- PMID: 33781504
- DOI: 10.1016/j.nec.2021.01.003
Abstract
Peptide and dendritic cell vaccines activate the immune system against tumor antigens to combat brain tumors. Vaccines stimulate a systemic immune response by inducing both antitumor T cells as well as humoral immunity through antibody production to cross the blood-brain barrier and combat brain tumors. Recent trials investigating vaccines against peptides (ie, epithelial growth factor receptor variant III, survivin, heat shock proteins, or personalized tumor antigens) and dendritic cells pulsed with known peptides, messenger RNA or unknown tumor lysate targets demonstrate the potential for therapeutic cancer vaccines to become an important therapy for brain tumor treatment.
Keywords: Brain tumor immunotherapy; Brain tumor vaccines; Dendritic cell vaccines; Peptide vaccines.
Copyright © 2021 Elsevier Inc. All rights reserved.
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